|
KMID : 0043319790020020099
|
|
Archives of Pharmacal Research
1979 Volume.2 No. 2 p.99 ~ p.110
|
|
|
The Crystal and Molecular Structure of Sulfapyridine
|
|
Koo CH
Lee YJ
|
|
|
Abstract
|
|
|
|
The crystal structure of sulfapyridine, C11 H11N3O2S, has been determined by X-ray diffraction method. The compound crystallizes in the monoclinic space group C2/c with a = 12.80(4), b = 11.72(4), c = 15.36(5)angstrom, P=94(3)o and Z=8. A total of 1133 observed reflections were collected by the Weissenberg method with CuK alpha radiation. Structure was solved by the heavy atom method and refined by isotropic block-diagonal least-squares method to the R value of 0.14. The nitrogen in the pyridine ring of sulfapyridine is associated with an extra-annular hydrogen. The C (benzene ring)-S-N-C(pyridine ring) group adopts the gauche form with a conformational angle of 71o. The benzene ring are inclined at angle of 84o to the pyridine ring plane. Sulfapyridine shows three different hydrogen bonding in the crystal. They are two N-H...O hydrogen bonds with the distance of 2.90 and 2.98angstrom respectively, and one N-H...N with the distance of 3.06 angstrom.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|